不需預熱、非侵入式無創(chuàng)大小鼠血壓儀
特色:
1. 一般很難量到血壓的colored mice (如 C57 BL/6)，倉鼠(麻醉)及天竺鼠(無麻醉)，使用
Muromachi MK-2000ST都可以測得到其血壓。
3. 測量老鼠尾部血壓不需再加熱，室溫23°C以上即可。
4. 操作簡單，可設定手動或自動連續(xù)測量。
5. 測量時顯示脈波圖，測量結果數(shù)字顯示：收縮壓、平均血壓、舒張壓及心跳。
6. 內(nèi)建快速打印機，可即時打印結果，并可用串口將數(shù)據(jù)傳至電腦。
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tail-cuff method without heating, (尾部測量) (MK-2000ST) |
Conventional heating tail-cuff method, (unanesthetized rats with heating) (尾部測量) |
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特色： l 當周邊環(huán)境溫度高于23 °C 時，不需要將實驗動物加熱 l 目前市面上，**可同時量mice & rat的儀器 l 方法簡單，設備不昂貴
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特色： l 需要將老鼠加熱 l 方法簡單，設備不昂貴 缺點： l 加熱的過程或限制動物移動的行為，可能會對老鼠造成壓迫(stress-induced)，使得其血壓受到影響，并可能傷害老鼠的健康
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Telemetry method, (unanesthetized restrained rats without heating) (遙測技術) |
Carotid arterial catheter method, (anesthetized rats, carotid arterial cannulation) (動脈導管技術) |
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特色： l 適用于心血管**鼠的量測，因為不會對老鼠產(chǎn)生壓迫，造成血壓改變 l 對于心血管的研究相當有用 l 不限制老鼠活動范圍 缺點： l 要將無線發(fā)送器植入老鼠腹部，而儀器也相當昂貴 |
特色： l 可直接量測到BP & HR
l 麻醉開腔插管手術可能會導致老鼠血壓、心跳、體溫降低
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主要特性：
1. 無創(chuàng)血壓儀兩種操作模式：
模式1 HR(心率)，模式2 SBP（收縮壓）
模式2中可以測量 HR/SBP/MBP(平均血壓)/DBP（舒張壓，計算值）
| MODE1 | HR | SBP | ||
| MODE2 | HR | SBP | MBP | (DBP) |
注意：HR (Heart Rate), SBP (Systolic BP), MBP (Mean BP),
DBP (Diastolic BP, calculated value)
2. 無創(chuàng)血壓儀連續(xù)測量功能：
連續(xù)測量可以*大到10次，此外為了得到更短的測量時間，也可以連續(xù)快速測量
3. 無創(chuàng)血壓儀快速打印功能：
屏幕上的數(shù)據(jù)包括平均值（AV）和標準差（SD），1秒鐘即可打印輸出
4. 患病動物也可測量（例如心肌梗塞的動物）
5. 無需多通道系統(tǒng)，只需要準備多重抑制劑，既可以很快測量
6. 一般很難量到血壓的有色老鼠colored mice (如 C57 BL/6)，倉鼠(麻醉)及
天竺鼠(無麻醉)，使用 Muromachi MK-2000ST都可以測得到其血壓。
7. 無創(chuàng)血壓儀自動序列功能：
動物的尾動脈血壓能夠自動監(jiān)測，時間間隔可以是1-99分鐘。每一次間隔，能夠
檢測1-10次。該全自動功能可以被輸出打印。
8. 時間印記功能：
MK-2000ST**記錄每一次BP測量的時間
9. 硬拷貝功能：
屏幕上顯示的一切都可以被拷屏打印，只需要摁一下PRTSCREEN按鍵
10. 串口連接：
DCS-2000數(shù)據(jù)采集軟件
11. 動物管是由黑色棕丙烯醛基制作，動物在相當安靜無干擾的環(huán)境下測量
12. 操作簡單
室町科技的大小鼠無創(chuàng)血壓儀是目前世界上*好的大小鼠無創(chuàng)血壓儀設備，分為兩種不同類型的大小鼠無創(chuàng)血壓儀，一種是無需預熱的大小鼠無創(chuàng)血壓儀，另外一種是便攜性經(jīng)濟型的大小鼠無創(chuàng)血壓儀。
Correlation between simultaneously recorded blood pressures (BP) from carotid catheter and BP measured with the Model MK-2000 in mice. Good correlation was seen in a wide range of BP, which was induced by i.v. infusions of pressor or depressor agents.
SPECIFICATIONS
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Main Unit (MK-2000ST) |
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| SBP | Cuff pressure when pulse reappears |
| MBP | Cuff pressure when pulse amplitude becomes largest |
| DBP | Calculated value based on SBP and MBP (3MBP-SBP)/2 |
| Detection | LED, Photo Transistor |
| Inflation Range | 0 - 350mmHg |
| Printer Outputs | Date, Time, Animal No., Weight, Operation Mode, Interval, No of Measuring Trials, Raw Data, Average and S.D. |
| Chart Paper |
Thermo-sensitive 58 mm Wide x 25m Long |
| Power | AC100-130V 50/60Hz |
| Dimensions | 210W x 310D x 210 mmH |
| Weight | Approx. 8 kg |
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Keyboard |
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| Function Keys | 33 |
| Dimensions | 145W x120D x20 mmH |
| Weight | Approx. 0.4 kg |
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The Standard System Comes Supplied with: |
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| Main Unit (Printer included) | 1 |
| Keyboard | 1 |
| Animal Holder (Any one from the list) | 1 |
| Cuff-pulse Sensor (Any one from the list) | 1 |
| Measuring Stand for Rats | 1 |
| TSP-10 Chart Paper (Pack of 5 Rolls) | 1 |
| APC-2000 Accessory Case | 1 |
| Dust Cover | 1 |
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利用本無創(chuàng)血壓儀儀器發(fā)表的參考文獻：
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Yuko Yamada, Nobuyuki Matoba, Hachiro Usui, Kunihiko Onishi, and Masaaki Yoshikawa
Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan
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Kazuo Kusugami?˜, Hidehiko Saito?˜ ?˜?˜, and Takashi Muramatsu?ö?÷?÷
From the ?öDepartment of Biochemistry, ?˜First Department of Internal Medicine, **Laboratory of Host Defense & Germfree Life, Research Institute for Disease Mechanism and Control, and ?ö?öInstitute for Laboratory Animal Research, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan, the ||Department of Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673,Japan, and the ?˜?˜Nagoya National Hospital, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan
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Progressive Development of Pulmonary Hypertension Leading to Right Ventricular Hypertrophy Assessed by Echocardiography in Rats (Exp. Anim. 52(4), 285-294, 2003)
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Takao NISHIZAWA2), Masahiko NISHIMURA2), and Mitsuhiro YOKOTA2)
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Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth (The Journal of Clinical Investigation July 2003 Vol.112, No. 1)
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Toyojiro Matsuishi,1,2 and Tsutomu Imaizumi1,3
1 The Cardiovascular Research Institute,
2 Department of Pediatrics, and
3 Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
4 Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
5 Discovery Research Laboratory, Tanabe Seiyaku Co., Osaka, Japan
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Development of an in vivo Bioassay Method for Allergy-Preventive Substances using HEL-induced Blood Flow Decrease (Biol. Pharm. Bull)
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Takahiro Iwamoto1,3, Satomi Kita1,5, Jin Zhang2, Mordecai P Blaustein2, Yuji Arai4, Shigeru Yoshida5,
Koji wakimoto6, Issei Komuro7&Takeshi Katsuragi1
1 Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
2 Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
3 Department of Molecular Physiology, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan.
4 Department of Bioscience, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan.
5 Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama 330-8530, Japan.
6 Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka 532-8505, Japan.
7 Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
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The vascular relaxing effects of sevoflurane and isoflurane are more important in hypertensive than in normotensive rats (Canadian Journal of Anesthesia 51: 979-985, 2004)
Jingui Yu, MD*, Koji Ogawa, MD, Yasuyuki Tokinaga, MD*, Shizue Iwahashi, MD* and Yoshio Hatano, MD*
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Toshifumi Shimada, MD; Yoshiaki Takeshita, MD; Toyoaki Murohara, MD; Ken-ichiro Sasaki, MD;
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Yo-ichi Nabeshima, MD; Tsutomu Imaizumi, MD
From the Cardiovascular Research Institute (T.S., Y.T., T.M., K.-i.S., K.E., S.S., Y.K., H.I., T.I.), Kurume University, Kurume; the Department of Cardiology (T.M.), Nagoya University Graduate School of Medicine, Nagoya; and the Department of Pathology and Tumor Biology (Y.-i.N.), Kyoto University Graduate School of Medicine, Kyoto, Japan.
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Mahmoud M. Khattab Adel Mostafa Othman Al-Shabanah
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Tomoji Mashimo, Birger Voigt, Takashi Kuramoto, and Tadao Serikawa
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An X-Ray Diffraction Study on Mouse Cardiac Cross-Bridge Function In Vivo: Effects of Adrenergic ß-Stimulation (Biophysical Journal 90:1723-1728 (2006)
Ryuji Toh,* Masakazu Shinohara,* Tomofumi Takaya,* Tomoya Yamashita,* Shigeru Masuda,*
Seinosuke Kawashima,* Mitsuhiro Yokoyama,* and Naoto Yagiy
*Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine,Kobe 650-0017, Japan; and ySPring-8/JASRI, Sayo, Hyogo 679-5198, Japan
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Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice (Am J Physiol Lung Cell Mol Physiol 290: L59-L65, 2006.)
Shinsuke Murakami,1,2 Noritoshi Nagaya,1,3 Takefumi Itoh,2 Masaharu Kataoka,1 Takashi Iwase,1
Takeshi Horio,3 Yoshinori Miyahara,4 Yoshiki Sakai,5 Kenji Kangawa,6 and Hiroshi Kimura2
1Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research
Institute, Osaka; 2Second Department of Internal Medicine, Nara Medical University, Nara; 3Department of
Internal Medicine, National Cardiovascular Center, Osaka; 4Department of Cardiac Physiology, National
Cardiovascular Center Research Institute, Osaka; 5Ono Pharmaceutical Co., Ltd. Research Headquarters,
Osaka; and 6Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
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Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory Peptide Obtained from Hen Ovotransferrin (Journal of the Chinese Chemical Society, 2006, 53, 495-501)
Nai-Yuan Leea, Juei-Tang Chengb, Toshiki Enomotoc, Ichiro Nakamurad,
a Livestock Research Institute, Tainan 712, Taiwan, R.O.C.
b Department Pharmacology, College of Medicine, National Cheng Kung University,
Tainan 70101, Taiwan, R.O.C.
c Department of Food Science, Ishikawa Prefectural University, Nonoichi, Ishikawa 9218836, Japan
d Institute of Animal Experimentation, School of Medicine, Hokkaido University, Sapporo 0608589, Japan
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Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats (Biol. Pharm. Bull. 29(8) 1756-1758 (2006) Vol. 29, No. 8
KUBOTA Yoko1 UMEGAKI Keizo2 KAGOTA Satomi 3 TANAKA Naoko 4 NAKAMURA Kazuki 5 KUNITOMO Masaru 6 SHINOZUKA Kazumasa 7
1 Department of Biopharmaceutics, Nihon Pharmaceutical University
2 National Institute of Health and Nutrition
3 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
4 Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
5 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
6 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
7 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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Richard D. Bland, Lucia M. Mokres, Robert Ertsey, Berit E. Jacobson, Shu Jiang, Marlene Rabinovitch,
Liwen Xu, Eric S. Shinwell, Feijie Zhang, and Matthew A. Beasley
Department of Pediatrics, Stanford University School of Medicine, Stanford, California
19. Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of
newborn mice.
(Am J Physiol Lung Cell Mol Physiol 294:L3-L14, 2008. )
Richard D. Bland, Robert Ertsey, Lucia M. Mokres, Liwen Xu, Berit E. Jacobson, Shu Jiang,
Cristina M. Alvira, Marlene Rabinovitch, Eric S. Shinwell, and Anjali Dixit
Department of Pediatrics, Stanford University School of Medicine, Stanford, California
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