產(chǎn)品詳情
簡單介紹：
Apex 396平行合成儀是美國老牌多肽合成儀制造商AAPPTEC公司的成熟產(chǎn)品。美國AAPTEC公司在全球多肽領(lǐng)域擁有**的科技，經(jīng)過近30年的發(fā)展，產(chǎn)品系列豐富合理，從單到多通道多肽合成儀質(zhì)量可靠，應(yīng)用便捷滿足不同客戶的需求，全球已經(jīng)有近萬臺我們的產(chǎn)品在正常運行。Apex 396平行合成儀能夠勝任液體，固相多肽以及有機合成反應(yīng)，具備多通道反應(yīng)器，自然基因科技擁有經(jīng)過廠家培訓(xùn)的專業(yè)技術(shù)人員。
詳情介紹：
美國AAPPTec公司
Apex 396平行合成儀
全自動多功能多肽合成儀
Apex 396平行合成儀，也稱396多功能多肽合成儀是目前世界上平行多肽合成和單通道多肽合成儀的市場**。Apex 396平行合成儀是作為生產(chǎn)**研發(fā)庫、丙氨酸掃描alanine scans、抗原表位定位和多肽平行試驗庫的理想儀器。合成規(guī)模從15毫克到2克。
高產(chǎn)量：
由于特氟龍反應(yīng)器的獨特設(shè)計，樹脂停留在反應(yīng)器底部，可以充分接觸反應(yīng)溶劑。基于這一點，樹脂不會粘在反應(yīng)器的邊緣，因此Apex 396平行合成儀能夠生產(chǎn)出更高產(chǎn)量的高純度多肽。
高效率：
當(dāng)維持一個惰性化境時，大氣氮氣輔助底部過濾能快速和徹底地排清反應(yīng)器，結(jié)果就是快速清空。這個處理，結(jié)合快速輸送，減少多肽樹脂分解應(yīng)歸于延長和酸的接觸或者高效率徹底的清洗樹脂以防止雜質(zhì)轉(zhuǎn)移。
高質(zhì)量：
這些特性與優(yōu)點使得Apex 396平行合成儀成為全自動環(huán)境溫度平行多肽合成儀的理想選擇。
Apex 396平行合成儀是一個易于使用的自動化液體處理系統(tǒng)，能夠勝任對液態(tài)、固相肽合成和有機合成反應(yīng)。所有試劑、反應(yīng)容器均在鋁合金密封艙里，因此無需額外的通風(fēng)櫥設(shè)備。
Apex 396平行合成儀支持多達96個化合物可以在四氟乙烯塊內(nèi)同時合成，同時也可以在40孔、16孔和8孔模式中選擇合成。
Apex 396平行合成儀在96孔反應(yīng)模式下，合成時間平均為30摩爾肽，每個肽20分鐘。依據(jù)化學(xué)合成過程，氨基酸循環(huán)累加時間范圍從45分鐘到1.5個小時。
.JPG)
Apex 396平行合成儀在96孔反應(yīng)模式下，合成時間平均為30摩爾肽，每個肽20分鐘。依據(jù)化學(xué)合成過程，氨基酸循環(huán)累加時間范圍從45分鐘到1.5個小時。
Apex 396平行合成儀同軸噴霧探頭傳輸溶劑**度達到了0.5毫升。同軸探頭有兩個通道：用于溶劑和其他用于惰性氣體（氮氣或者氬氣）。在溶劑送氣過程中排出的溶劑替換為惰性氣體；在溶劑傳輸過程中，氣體保持貫徹整個合成。探頭還負責(zé)液體的檢測，通過鑒定測量溶劑的電容率。這可確保探頭進入液面一下的溶劑，探頭接觸減少可減少寶貴樣品之間的交叉污染。
Apex 396平行合成儀反應(yīng)容器通過正壓的氮氣壓力被**干凈，保持一種惰性環(huán)境并確保能有效去除容器底部的所溶劑和試劑。
Apex 396平行合成儀范圍有四種模式：
Apex 396-SC: 單臂和經(jīng)典反應(yīng)器
Apex 396-DC: 雙臂和經(jīng)典反應(yīng)器
Apex 396-DC-FW-S: 雙臂系統(tǒng)，經(jīng)典反應(yīng)器，快洗功能和**臂單針探頭
Apex 396-DC-FW-M: 雙臂系統(tǒng)，經(jīng)典反應(yīng)器，快洗功能和**臂多針探頭
Apex 396平行合成儀基于其可靠性、耐用性、易用性和高性能。高品質(zhì)的純鈦可以容易和快速的合成。所有類型的肽和有機化學(xué)反應(yīng)都可以在這個高度靈活的桌面單元操作。
主要特點：
? 多種肽合成執(zhí)行液體和固相化學(xué)合成
? 1-96化合物可同時合成
? 多種氨基酸和反應(yīng)容器配置
? 桌面多肽合成
? 全封閉罩，包含煙霧和有害氣味
? 模式桌面試劑放置允許極大的靈活性
? 自動切割FMOC-化學(xué)
? 稀釋器/注射器配藥系統(tǒng)微升精度
? 雙臂機器人可利用單或多探頭在**臂上
主要技術(shù)參數(shù)：
? 可變規(guī)模合成
? 變速漩渦混合反應(yīng)塊，300-1200轉(zhuǎn)/分鐘
? 聚四氟乙烯不粘表面和惰性環(huán)境反應(yīng)器
? 樣品過濾聚四氟乙烯反應(yīng)器熔塊
? 隔墊反應(yīng)孔維持壓，防止交叉污染，并減少溶劑損失
? 鋁制模式桌面允許靈活的試劑位置
? 多達6大部分外部溶劑線
? 350毫升和800毫升的試劑瓶
? 兩個溶劑試劑稀釋器在**個手臂上（在所有APEX型號）
? 用于來自稀釋器的溶劑輸送齒輪泵
? 準(zhǔn)確的溶劑輸送直到0.5升
? 同軸噴霧探頭用于溶劑輸送和液體檢測
? 探頭清洗站，以防止交叉污染
? 輔助氮正壓力容器在不到1分鐘排空
? 氮和溶劑的檢測系統(tǒng)，以防止在試劑缺乏的情況下操作
? 快速請洗功能，在雙臂的Apex型號，在96反應(yīng)孔1-1.5分鐘
? 直觀的易于使用和編程簡單的軟件，指向和點擊命令
主要選項：
可選配件：
聚四氟乙烯反應(yīng)孔：96，40，16和8
? 樹脂分配器：35毫克或70毫克可用
? 單體架：4x9架使用35毫升瓶，8X12架使用10毫升瓶，
2X5架使用25毫升瓶，5X6架使用125毫升瓶裝。
可定制機架。
2X5架使用25毫升瓶，5X6架使用125毫升瓶裝。
可定制機架。
? 酶標(biāo)塊96孔板的送樣
? 樣品的沉積、樹脂切割，適用于96×4 ml樣品瓶，40×6毫升小瓶，16×15毫升的小瓶和8×35毫升小瓶
靈活性：
* Apex 396平行合成儀既可以生產(chǎn)單個肽，也可以同時生產(chǎn)少量肽或者同時
生產(chǎn)多達96個肽。
* 雙機器人臂精準(zhǔn)的在任意兩個點之間傳輸試劑。
* 密封罩內(nèi)可以靈活地使用任何形狀，尺寸或者放置容器
* Apex 396平行合成儀可以靈活的支持任何化學(xué)類型，包括預(yù)激活氨基酸
混合模式：
* Apex 396平行合成儀具備柔和但是高效的渦旋混合可以完全混合樹脂和試劑
* Apex 396平行合成儀渦旋混合提供了高度的一致性和持續(xù)性，保障了高質(zhì)量高純肽和蛋白質(zhì)的生產(chǎn)。
Apex 396平行合成儀是當(dāng)今市場上**的多肽合成儀。
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
關(guān)于美國AAPPTEC公司：
美國AAPPTEC公司，英文全稱為Advanced Automated Peptide Protein Technologies公司,即美國先進自動多肽蛋白技術(shù)公司成立于2005年3月，公司的前身是ACT（Advanced ChemTech）公司的儀器部。AAPPTEC公司購買了前ACT公司儀器的全部資產(chǎn)，包括生產(chǎn)線，**權(quán)以及在生產(chǎn)、促銷和服務(wù)等方面的**特權(quán)。AAPPTEC公司投入了充足的資源去提升和改進設(shè)備生產(chǎn)線，與此同時為藥學(xué)界和生物領(lǐng)域提供了眾多**性新產(chǎn)品。
AAPPTEC公司極其前身一直由Hossain Saneii博士來管理和運作整個公司，其總部設(shè)在美國肯塔吉州的路易斯維爾。近20年里，AAPPTEC公司在全自動多肽合成儀領(lǐng)域，針對不同的需求研發(fā)出數(shù)十種類型的儀器，加上長期實際應(yīng)用驗證的可靠性，這些儀器均可滿足不同客戶的不同需求，而且使用起來都相當(dāng)便利，得到了全球用戶的一致好評。AAPPTEC公司的多肽合成儀一定會滿足您的需要，無論從儀器本身，到合成技術(shù)，到售后服務(wù)，我們在美國的工程師以及中國本土的高水平科學(xué)工作者也會一如既往地為您提供專業(yè)、周到的服務(wù)。
* 自然基因科技自2012年9月開始總代理美國AAPPTEC公司的產(chǎn)品。*
本產(chǎn)品提供1年全免費售后服務(wù)，包括產(chǎn)品介紹、送貨、安裝、調(diào)試、維修、技術(shù)培訓(xùn)服務(wù)等（與客戶有特殊約定的按照約定執(zhí)行）。
我們的標(biāo)準(zhǔn)服務(wù)流程為：
l 儀器完好無損運送到客戶處
l 專業(yè)工程師接到派工單，與客戶主動聯(lián)系：了解客戶現(xiàn)場情況、告知客戶需要準(zhǔn)備的必要條件、與客戶約定安裝培訓(xùn)時間
l 專業(yè)工程師到達客戶現(xiàn)場，向客戶主動出示工作證件和安裝培訓(xùn)執(zhí)照
l 專業(yè)工程師檢查貨物包裝情況，按照合同與客戶一起清點貨物
l 在客戶指定的符合儀器運行條件的位置，安裝儀器
l 測試電壓并開機試運行儀器
l 向客戶介紹各個硬件組成部分
l 向客戶介紹儀器的硬件操作
l 培訓(xùn)客戶使用軟件
l 向客戶告知儀器運行注意事項與保養(yǎng)規(guī)則
l 回答客戶疑問
l 陪同客戶試用儀器
l 與客戶一起簽署工作報告、保修單與驗收報告
l 將服務(wù)聯(lián)系標(biāo)牌貼在醒目位置，便于客戶聯(lián)系工程師
l 2-4周后回訪客戶，并解答客戶提出的在使用中出現(xiàn)的問題
尊重客戶，理解客戶，一切從客戶角度出發(fā)，持續(xù)提供超越客戶期望的產(chǎn)品與服務(wù)，做客戶們永遠的伙伴。這是我們一直堅持和倡導(dǎo)的服務(wù)理念。
l 心中永遠首先想到的是客戶，我們提到的質(zhì)量不僅僅指產(chǎn)品的內(nèi)在質(zhì)量，還包括產(chǎn)品的包裝質(zhì)量、服務(wù)質(zhì)量等一系列因素。因此必須**地滿足客戶的需求。
l 應(yīng)站在客戶的立場，而不是站在公司的立場上去研究、設(shè)計和改進服務(wù)。
l 完善服務(wù)系統(tǒng)，加強售前、售中、售后服務(wù)，對客戶在使用中出現(xiàn)的各種問題及時幫助解決，使客戶感到極大方便。
l 高度重視客戶意見，把處理客戶的意見作為使顧客滿意的重要一環(huán)。
l 5S理念：“5S”是指“微笑（SMILE）、迅速（SPEED）、誠實（SINCERITY）、靈巧（SMART）、研究（STUDY）”五個詞語英文首字母的縮寫。“5S”理念是代表性的服務(wù)文化**，不僅具有人性化十足的時代特點，還具備相當(dāng)?shù)目刹僮餍浴?/span>
|
品質(zhì)承諾
|
運送說明
|
售后服務(wù)
|
服務(wù)理念
|
聯(lián)系我們
|
|
實物拍照力求真實
全新原廠**進口 產(chǎn)品功能如實描述 |
國際專業(yè)貨運快遞服務(wù)
運保費如實收取極優(yōu)惠 貨期短包裝厚實極** |
專業(yè)工程師上門安裝
壹年全免費保修服務(wù) 365天上門培訓(xùn)服務(wù) |
服務(wù)專業(yè)、業(yè)務(wù)厚道
尊重客戶、理解客戶 值得您信賴的服務(wù)商 |
電話：010-51650521
傳真：010-51650521 郵件:info@naturegene.com |
自然基因科技總代產(chǎn)品，請聯(lián)系：
010 – 51650520
info@naturegene.com
附錄：參考文獻---誰在使用這臺儀器？
Apex 396平行合成儀文獻
Parekh, SH; Chatterjee, K; Lin-Gibson, S; Moore, NM; Cicerone, MT; Young, MF; Simon, CG., Jr.
“Modulus-Driven Differentiation of Marrow Stromal Cells in 3D Scaffolds that is Independent of
Myosin-Based Cytoskeletal Tension” Biomaterials, 2011, 32, 2256-2264.
Patel, D; Menon, R; Taite, LJ. “Self-Assembly of Elastin-Based Peptides into the ECM: the
Importance of Integrins and the Elastin Binding Protein in Elastic Fiber Assembly”
Biomacromolecules, 2011, 12, 432-440.
Yu, Z; Zhao, W; Liu, J; Lu, J; Chen, F. “QIGLF, a Novel Angiotensin I-Converting Enzyme-
Inhibitory Peptide From Egg White Protein” J. Sci. Food Agricul., 2011, 91, 921-926.
Anderson, JM; Vines, JB; Patterson, JL; Chen, H; Javed, A; Jun, H-W. “Osteogenic Differentiation
of Human Mesenchymal Stem Cells Synergystically Enhanced by Biomimetic Peptide
Amphiphiles Combined with Conditioned Medium” Acta Biomater., 2011, 7, 675-682.
Saik, JE; Gould, DJ; Watkins, EM; Dickinson, ME; West, JL. “Covalently Immobilized Platelet-
Derived Growth Factor BB Promotes Angiogenesis in Biomimetic Poly(Ethylene Glycol)
Hydrogels” Acta Biomater., 2011, 7, 133-143.
Aranda, F; Llopiz, D; Díaz-Valdés, N; Riezu-Boj, JI; Bezunartea, J; Ruiz, M; Martínez, M;
Durantez, M; Mansilla, C; Prieto, J; Lasarte, JJ; Borrás-Cuesta, F; Sarobe, P, “Adjuvant
Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity TCell
Responses against Poorly Immunogenic Tumors” Cancer Res., 2011, 71, 3214 - 3224.
Lu, C; Williams, A; Chan, S; McFarland, M; Gomez-Lemus, J; Chin, J; Izawa, J; Luyt, L; Lewis, J,
“2317 Ghrelin Receptor Labling as a Novel Imaging Marker for Prostatic Neoplasms” The Journal
of Urology, 2011, 185, Supplement 1, e92.
Moore, NM; Lin, NJ; Gallant, ND; Becker, ML, “Synergistic enhancement of human bone marrow
stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide
concentration gradients” Acta Biomaterialia, 2011, 7, 2091-2100.
Fridkin, G; Maina, T; Nock, BA; Blat, D; Lev-Goldman, V; Scolnik, Y; Kapitkovski, A; Vachutinsky,
Y; Shechter, Y; Levy, Y, “Intramolecular azo-bridge as a cystine disulfide bond surrogate:
Somatostatin-14 and brain natriuretic peptide (BNP) analogs” Bioorganic & Medicinal Chemistry,
2011, 19, 798-806.
Andukuri, A; Kushwaha, M; Tambralli, A; Anderson, JM; Dean, DR; Berry, JL; Sohn, YD; Yoon, YS;
Brott, BC; Jun, H-W, “A hybrid biomimetic nanomatrix composed of electrospun
polycaprolactone and bioactive peptide amphiphiles for cardiovascular implants” Acta
Biomaterialia, 2011, 7, 225-233.
Anderson, JM; Vines, JB; Patterson, JL; Chen, H; Javed, A; Jun, H-W, “Osteogenic differentiation
of human mesenchymal stem cells synergistically enhanced by biomimetic peptide amphiphiles
combined with conditioned medium” Acta Biomaterialia, 2011, 7, 675-68.
Wang, Y; Bakota, E; Chang, BHJ; Entman, M; Hartgerink, JD; Danesh, FR, “Peptide Nanofibers
Preconditioned with Stem Cell Secretome Are Renoprotective” J. Am. Soc. Nephrol., 2011, 22,
704 - 717.
O’Leary, LER; Fallas, JA Hartgerink, JD, “Positive and Negative Design Leads to Compositional
Control in AAB Collagen Heterotrimers” J. Am. Chem. Soc., 2011, 133, 5432–5443.
Guilherme, L; Alba, MP; Ferreira, FM; Oshiro, SE; Higa, F; Patarroyo, ME; Kalil, J, “Anti-Group A
Streptococcal Vaccine Epitope: Structure, Stability, and Its Ability to Interact With HLA Class II
Molecules” J. Biol. Chem., 2011, 286, 6989-6998.
Saik, JE; Gould, DJ; Watkins, EM; Dickinson, ME; West, JL, “Covalently immobilized plateletderived
growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels”
Acta Biomaterialia, 2011, 7, 133-143.
Bradshaw, RT; Patel, BH; Tate, EW; Leatherbarrow, RJ; Gould, IR, “Comparing experimental and
computational alanine scanning techniques for probing a prototypical protein–protein interaction”
Protein Eng. Des. Sel., 2011, 24, 197-207.
Parekh, SH; Chatterjee, K; Lin-Gibson, S; Moore, NM; Cicerone, MT; Young, MF; Simon, CG, Jr.,
“Modulus-driven differentiation of marrow stromal cells in 3D scaffolds that is independent of
myosin-based cytoskeletal tension” Biomaterials, 2011, 32, 2256-2264.
Ponnaluri, VKC; Vavilala, DT; Mukherji, M, “Studies on substrate specificity of Jmjd2a-c histone
demethylases” Biochemical and Biophysical Research Communications, 2011, 405, 588-592.
Wang, H; Xu, K; Liu, L; Tan, JPK; Chen, Y; Li, Y; Fan, W; Wei, Z; Sheng, J; Yang, Y-Y; Li,L. “The
Efficacy of Self-Assembled Cationic Antimicrobial Peptide Nanoparticles Against Cryptococcus
neoformans for the Treatment of Meningitis” Biomaterials, 2010, 31, 2874-2881.
Moore, NM; Lin, NJ; Gallant, ND; Becker, ML. “The Use of Immobilized Osteogenic Growth
Peptide on Gradient Substrates Synthesized Via Click Chemistry to Enhance MC3T3-E1
Osteoblast Proliferation” Biomaterials, 2010,
Ghadial, JE; Cohen, BE; Stevens, MM. “Protein Kinase-Actuated Resonance Energy Transfer in
Quantum Dot-Peptide Conjugates” ACS Nano, 2010, 4, 4915-9.
Brims, DR; Qian, J; Jarchum, I; Mikesh, L; Palmieri, E; Ramagopal, UA; Malashkevich, VN;
Chaparro, RJ; Lund, T; Hattori, M; Shabanowitz, J; Hunt, DF; Nathenson, SG; Almo, SC;
DiLorenzo, TP, “Predominant occupation of the class I MHC molecule H-2Kwm7 with a single
self-peptide suggests a mechanism for its diabetes-protective effect” Int. Immunol., 2010; 22,
191-203.
Amadi, GA; Cho, C-F; Lewis, JD; Luyt, LG. “A Fast, Reproducible and Low-Cost Method For
Sequence Deconvolution of ‘On-Bead’ Peptides Via ‘On-Target’ Maldi-TOF/TOF Mass
Spectrometry” J. Mass Spect., 2010, 45, 241-51.
Godugu, B; Neta, P; Simón-Manso, Y; Stein, SE. “Effect of N-Terminal Glutamic Acid and
Glutamine on Fragmentation of Peptide Ions” J. Am. Soc. Mass Spect., 2010, 1169-1176.
Rosales, AM; Murnen, HK; Zuckermann, RN; Segalman, RA. “Control of Crystallization and
Melting Behavior in Sequence Specific Polypeptoids” Macromolecules, 2010, 43, 5627-36.
Murnen, HK; Rosales, AM; Jaworski, JN; Segalman, RA; Zuckermann, RN. “Heirachical Self-
Assembly of a Biomimetic Diblock Copolypeptoid into Homochiral Superhelices” J. Am. Chem.
Soc., 2010, 132, 16112-9.
Azad, BB; Rota, VA; Breadner, D; Dhanvantari, S; Luyt, LG. “Design, Synthesis and in vitro
Characterization of Glucagon-Like Peptide-1 Derivatives for Pancratic Beta Cell Imaging by
SPECT” Bioorg. Med. Chem., 2010, 18, 1265-1272.
Feliu, L; Oliveras, G; Cirac, AD; Besalú, E; Rosés, C; Colomer, R; Bardají, E; Planas, M; Puig, T,
“Antimicrobial cyclic decapeptides with anticancer activity” Peptides, 2010, 31, 2017-202.
Guzman, E; Taylor, G; Charleston, B; Ellis, SA, “Induction of a Cross-Reactive CD8+ T Cell
Response following Foot-and-Mouth Disease Virus Vaccination” J. Virol., 2010, 84, 12375-12384.
Galler, KM; Aulisa, L; Regan, KR; D’Souza, RN; Hartgerink, JD, “Self-Assembling Multidomain
Peptide Hydrogels: Designed Susceptibility to Enzymatic Cleavage Allows Enhanced Cell
Migration and Spreading” J. Am. Chem. Soc., 2010, 132, 3217–3223.
Kushwaha, M; Anderson, JM; Bosworth, CA; Andukuri, A; Minor, WP; Lancaster, JR, Jr.;
Anderson, PG; Brott, BC; Jun, H-W, “A nitric oxide releasing, self assembled peptide amphiphile
matrix that mimics native endothelium for coating implantable cardiovascular devices”
Biomaterials, 2010, 31, 1502-1508.
Weiger, MC; Park, JJ; Roy, MD; Stafford, CM; Karim, A; Becker, ML, “Quantification of the
binding affinity of a specific hydroxyapatite binding peptide” Biomaterials, 2010, 31, 2955-2963.
Choi, Y-S; Lee, JY; Suh, JS; Kwon, Y-M; Lee, S-J; Chung, J-K; Lee, D-S; Yang, VC; Chung, C-P;
Park, Y-J, “The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight
protamine” Biomaterials, 2010, 31, 1429-1443.
Andukuri, A; Minor, WP; Kushwaha, M; Anderson, JM; Jun, H-W, “Effect of endothelium
mimicking self-assembled nanomatrices on cell adhesion and spreading of human endothelial
cells and smooth muscle cells” Nanomedicine: Nanotechnology, Biology and Medicine, 2010, 6,
289-297.
Rubin, N; Perugia, E; Wolf, SG; Klein, E; Fridkin, M; Addadi, L, “Relation between Serum Amyloid
A Truncated Peptides and Their Suprastructure Chirality” J. Am. Chem. Soc., 2010, 132, 4242–
4248.
So, S; Peeva, LG; Tate, EW; Leatherbarrow, RJ; Livingston, AG, “Organic Solvent Nanofiltration:
A New Paradigm in Peptide Synthesis” Org. Process Res. Dev., 2010, 14, 1313–1325.
Baumhover, NJ; Anderson, K; Fernandez, CA; Rice, KG, “Synthesis and In Vitro Testing of New
Potent Polyacridine?Melittin Gene Delivery Peptides” Bioconjugate Chem., 2010, 21, 74–83.
Godugu, B; Neta, P; Simón-Manso, Y; Stein, SE, “Effect of N-Terminal Glutamic Acid and
Glutamine on Fragmentation of Peptide Ions” Journal of the American Society for Mass
Spectrometry, 2010, 21, 1169-1176.
Ghadiali, JE; Cohen, BE; Stevens, MM, “Protein Kinase-Actuated Resonance Energy Transfer in
Quantum Dot?Peptide Conjugates” ACS Nano, 2010, 4, 4915–4919.
Moore, NM; Lin, NJ; Gallant, ND; Becker, ML, “The use of immobilized osteogenic growth peptide
on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast
proliferation” Biomaterials, 2010, 31, 1604-1611.
Choi, YJ; Lee, JY; Park, JH; Park, JB; Suh, JS; Choi, YS; Lee, SJ; Chung, C-P; Park, YJ, “The
identification of a heparin binding domain peptide from bone morphogenetic protein-4 and its role
on osteogenesis” Biomaterials, 2010, 31, 7226-7238.
Anderson, K; Fernandez, C; Rice, KG, “N-Glycan Targeted Gene Delivery to the Dendritic Cell
SIGN Receptor” Bioconjugate Chem., 2010, 21, 1479–1485.
Fernandez, CA; Baumhover, NJ; Anderson, K; Rice, KG, “Discovery of Metabolically Stabilized
Electronegative Polyacridine-PEG Peptide DNA Open Polyplexes” Bioconjugate Chem., 2010,
21, 723–730.
Tait, S; Dutta, K; Cowburn, D; Warwicker, J; Doig, AJ; McCarthy, JEG, “Local control of a
disorder–order transition in 4E-BP1 underpins regulation of translation via eIF4E” PNAS, 2010,
107, 17627-17632.
He, J; Yarbrough, DK; Kreth, J; Anderson, MH, Shi, W; Eckert, R, “Systematic Approach to
Optimizing Specifically Targeted Antimicrobial Peptides against Streptococcus mutans”
Antimicrob. Agents Chemother., 2010, 54, 2143-2151.
Wang, H; Xu, K; Liu, L; Tan, JPK; Chen, Y; Li, Y; Fan, W; Wei, Z; Sheng, J; Yang, Y-Y; Li, L, “The
efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus
neoformans for the treatment of meningitis” Biomaterials, 2010, 31, 2874-2881.
Azad, BB; Rota, VA; Breadner, B; Dhanvantari, S; Luyt, LG, “Design, synthesis and in vitro
characterization of Glucagon-Like Peptide-1 derivatives for pancreatic beta cell imaging by
SPECT” Bioorganic & Medicinal Chemistry, 2010, 18, 1265-1272.
Guilherme, L; Postol, E; Freschi de Barros, S; Higa, F; Alencar, R; Lastre, M; Zayas, C; Puschel,
CR; Silva, WR; Sa-Rocha, LC; Sa-Rocha, VM; Pérez, O; Kalil, J. “A vaccine against S. pyogenes:
Design and experimental immune response” Methods, 2009, 49, 316-321.
Duryee, MJ; Bevins, RA; Reichel, CM; Murray, JE; Dong, Y; Thiele, GM; Sanderson, SD,
“Immune responses to methamphetamine by active immunization with peptide-based, molecular
adjuvant-containing vaccines” Vaccine, 2009, 27, 2981-2988.
Fallas, JA; Gauba, V; Hartgerink, JD, “Solution Structure of an ABC Collagen Heterotrimer
Reveals a Single-register Helix Stabilized by Electrostatic Interactions” J. Biol. Chem., 2009, 284,
26851-26859.
Rosita, D; DeWit, MA; Luyt, LG, “Fluorine and Rhenium Substituted Ghrelin Analogues as
Potential Imaging Probes for the Growth Hormone Secretagogue Receptor” J. Med. Chem., 2009,
52, 2196–2203.
Lee, J-Y; Choo, J-E; Choi, Y-S; Suh, J-S; Lee, S-J; Chung, C-P; Park, Y-J, “Osteoblastic
differentiation of human bone marrow stromal cells in self-assembled BMP-2 receptor-binding
peptide-amphiphiles” Biomaterials, 2009, 30, 3532-3541.
Kim, J-K; Anderson, J; Jun, H-W; Repka, MA; Jo, S, “Self-Assembling Peptide Amphiphile-Based
Nanofiber Gel for Bioresponsive Cisplatin Delivery” Mol. Pharmaceutics, 2009, 6, 978–985.
Lopes, LB; Flynn, C; Komalavilas, P; Panitch, A; Brophy, CM; Seal, BL, “Inhibition of HSP27
phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor” Biochemical and Biophysical
Research Communications, 2009, 382, 535-539.
LeBeau, AM; Banerjee, SR; Pomper, MG; Mease, RC; Denmeade, SR, “Optimization of peptidebased
inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate
cancer” Bioorganic & Medicinal Chemistry, 2009, 17, 4888-489.
Tam, RY; Rowley, CN; Petrov, I; Zhang, T; Afagh, NA; Woo, TK; Ben, RN, “Solution
Conformation of C-Linked Antifreeze Glycoprotein Analogues and Modulation of Ice
Recrystallization” J. Am. Chem. Soc., 2009, 131, 15745–15753.
Bakota, EL; Aulisa, L; Tsyboulski, DA; R. Weisman, RB; Hartgerink, JD, “Multidomain Peptides as
Single-Walled Carbon Nanotube Surfactants in Cell Culture” Biomacromolecules, 2009, 10,
2201–2206.
Duryee, MJ; Bevins, RA; Reichel, CM; Murray, JE, Dong, Y; Thiele, GM; Sanderson SD. “Immune
Responses to Methamphetamine by Active Immunization with Peptide-Based, Molecular
Adjuvant-Containing Vaccines” Vaccine, 2009, 27, 2981-2988.
LeBeau, AM; Banerjee, SR; Pomper, MG; Mease, RC; Denmeade, SR. “Optimization of Peptide-
Based Inhibitors of Prostate-Specific Antigen (PSA) as Targeted Imaging Agents for Prostate
Cancer” Bioorg. Med. Chem. Letters, 2009, 17, 4888-4893.
LeBeau, AM; Brennen, WN; Aggarwal, S; Denmeade, SR, “Targeting the cancer stroma with a
fibroblast activation protein-activated promelittin protoxin” Mol. Cancer Ther. 2009, 8, 1378-1386.
Lopes, LB; Flynn, C; Komalavilas, P; Panitch, A; Brophy, CM; Seal, BL. “Inhibition of HSP27
Phosphorylation by a Cell-Permeant MAPKAP Kinase 2 Inhibitor” Biochem. Biophys. Res.
Commun., 2009, 382, 535-539.
Phillips, JA; Morgan, EL; Dong, Y; Cole, GT; McMahan, C; Hung C-Y; Sanderson, SD. “Single-
Step Conjugation of Bioactive Peptides to Proteins via a Self-Contained Succinimidyl Bis-
Arylhydrazone” Bioconjugate Chem., 2009, 20, 1950–1957.
Wang, D; Fang, S; Wohlhueter, RM. “N-Terminal Derivatization of Peptides with Isothiocyanate
Analogues Promoting Edman-Type Cleavage and Enhancing Sensitivity in Electrospray
Ionization Tandem Mass Spectrometry Analysis” Anal. Chem., 2009, 81, 1893–1900.
Ueda, T; Tomita, K; Notsu, Y; Ito, T; Fumoto, M; Takakura, T; Nagatome, H; Takimoto, A; Mihara,
S-I; Togame, H; Kawamoto, K; Iwasaki, T; Asakura, K; Oshima, T; Hanasaki, K, Nishimura S-I;
Kondo, H. “Chemoenzymatic Synthesis of Glycosylated Glucagon-like Peptide 1: Effect of
Glycosylation on Proteolytic Resistance and in Vivo Blood Glucose-Lowering Activity” J. Am.
Chem. Soc., 2009, 131, 6237–6245.
LeBeau, AM; Singh, P; Isaacs JT; Denmeade, SR. “Prostate-Specific Antigen Is a “Chymotrypsinlike”
Serine Protease with Unique P1 Substrate Specificity” Biochemistry, 2009, 48, 3490–3496.
Seow, WY; Yang, Y-Y. “A Class of Cationic Triblock Amphiphilic Oligopeptides as Efficient Gene-
Delivery Vectors” Advanced Mater., 2009, 21, 86-90.
Lui, S; Zhou, L; Chen, L; Dastidar, SG; Verma, C; Ll, J; Tan, D; Beuerman, R. “Effect of Structural
Parameters of Peptides on Dimer Formation and Highly Oxidized Side Products in the Oxidation
of Thiols of Linear Analogs of Human β-Defensin 3 by DMSO” J. Pept. Sci. 2009, 15, 95-106.
Kiviranta, PH; Suuronen, T; Walln, EAA; Leppnen, J; Tervonen, J; Kyrylenko, S; Salminen, A;
Poso, A; Jarho, EM, “N-Thioactyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and
SIRT2 Inhibitors” J. Med. Chem., 2009, 52, 2153–2156
Román-Hernández, G; Grant, RA, Sauer, RT; Baker, TA, “Molecular basis of substrate selection
by the N-end rule adaptor protein ClpS” PNAS, 2009, 106, 8888 - 8893.
Ivanova, GD; Arzumanov, A; Abes, R; Yin, H; Wood, MJA; Lebleu, B; Gait, MJ, “Improved cellpenetrating
peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in
mdx mouse muscle” Nucleic Acids Res., 2008, 36, 6418-6428.
Wang, KH; Oakes, ESC; Sauer, RT; Baker, TA, “Tuning the Strength of a Bacterial N-end Rule
Degradation Signal” J. Biol. Chem., 2008, 283, 24600-24607.
Garcia, TCM; Fonseca, CT; Pacifico, LGG; Dur?es, FdV; Ant?nio F; Marinho, V; Penido, MLO;
Caliari, MV; de Melo, AL; Pinto, HA; Barsante, MM; Cunha-Neto, E; Oliveira, SC, “Peptides
containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of
immune response, reduction in liver pathology and partial protection against Schistosoma
mansoni infection in mice” Acta Tropica, 2008, 106, 162-167.
Romanini, DW; Francis, MB, “Attachment of Peptide Building Blocks to Proteins Through
Tyrosine Bioconjugation” Bioconjugate Chem., 2008, 19, 153–157.
Wei, F; Zhang, D; Halas, NJ; Hartgerink, JD, “Aromatic Amino Acids Providing Characteristic
Motifs in the Raman and SERS Spectroscopy of Peptides” J. Phys. Chem. B, 2008, 112, 9158–
9164.
Martin, ME; Rice, KG, “A Novel Class of Intrinsic Proteasome Inhibitory Gene Transfer Peptides”
Bioconjugate Chem., 2008, 19, 370–376.
Tsyboulski, DA; Bakota, EL; Witus, LS; Rocha, J-DR; Hartgerink, JD; Weisman, RB, “Self-
Assembling Peptide Coatings Designed for Highly Luminescent Suspension of Single-Walled
Carbon Nanotubes” J. Am. Chem. Soc., 2008, 130, 17134–17140.
Blat, D; Weiner, L; Youdim, MBH; Fridkin, M, “A Novel Iron-Chelating Derivative of the
Neuroprotective Peptide NAPVSIPQ Shows Superior Antioxidant and Antineurodegenerative
Capabilities” J. Med. Chem., 2008, 51, 126–134.
Fournier, F; Gardner, EM; Guo, R; Donaldson, PM; Barter, LMC; Palmer, DJ; Barnett, CJ;
Willison, KR; Gould, IR; Klug, DR, “Optical fingerprinting of peptides using two-dimensional
infrared spectroscopy: Proof of principle” Analytical Biochemistry, 2008, 374, 358-365.
Han, X; Shigaki, S; Yamaji, T; Yamanouchi, G; Mori, T; Niidome, T; Katayama, Y, “A quantitative
peptide array for evaluation of protein kinase activity” Analytical Biochemistry, 2008, 372, 106-
115.
Torres, O; Yüksel, D; Bernardina, M; Kumar, K; Bong, D. “Peptide Tertiary Structure Nucleation
by Side-Chain Crosslinking with Metal Complexation and Double “Click” Cycloaddition”
ChemBioChem. 2008, 9, 1701-1705.
Yu, MM; Wang, RF; Yan, P; Zhang, CL; Liu, M; Cui, YG. “Design, Synthesis and Iodination of an
Arg-Arg-Leu Peptide for Potential Use as an Imaging Agent for Human Prostate Carcenoma” J.
Labelled Comp. Radiopharm., 2008, 51, 374-378.
Liu, S; Zhou, L;, Li, J; Suresh, A; Verma, C; Foo, YH; Yap, EPH; Tan, DTH; Beuerman, RW.
“Linear Analogs of Human β-Defensin 3: Concepts for Design of Antimicrobial Peptides with
Reduced Cytotoxicity to Mammalian Cells” ChemBioChem. 2008, 9, 964-973.
Peng, W; Wang, HY; Miyahara, Y; Peng, G; Wang, R-F, “Tumor-Associated Galectin-3 Modulates
the Function of Tumor-Reactive T Cells” Cancer Res. 2008, 68, 7228-7236.
Greidinger, EL; Zang, YJ; Jaimes, K; Martinez, L; Nassiri, M; Hoffman, RW, “CD4+ T Cells Target
Epitopes Residing within the RNA-Binding Domain of the U1-70-kDa Small Nuclear
Ribonucleoprotein Autoantigen and Have Restricted TCR Diversity in an HLA-DR4-Transgenic
Murine Model of Mixed Connective Tissue Disease” J. Immunol. 2008, 180, 8444-8454.
Jahn-Schmid, B; Sirven, P; Leb, V; Pickl, WF; Fischer, GF; Gadermair, G; Egger, M; Ebner, C;
Ferreire, F: Maillére, B; Bohle, B. “Characterization of HLA Class II/Peptide-TCR Interactions of
the Immunodominant T Cell Epitope in Art v 1, the Major Mugwort Pollen Allergen” J. Immunol.
2008, 181, 3636-42.
Bernardina, M; Kumar, K; Bong, D; “Peptide Tertiary Structure by Side-Chain Crosslinking with
Metal Complexation and Double “Click” Cycloaddition” ChemBioChem, 2008, 9, 1701-5.
Shu, JY; Tan, C; DeGrado, WF; Xu, T. “New Design of Helix Bundle Peptide?Polymer
Conjugates” Biomacromolecules, 2008, 9, 2111–2117.
Gong, Y; Ma, M; Luo, Y; Bong, D, “Functional Determinants of a Synthetic Vesicle Fusion
System” J. Am. Chem. Soc., 2008, 130, 6196–6205.
Edwards, WB; Xu, B; Akers, W; Cheney, PP; Liang, K; Rogers, BE; Anderson, CJ; Achilefu, S,
“Agonist?Antagonist Dilemma in Molecular Imaging: Evaluation of a Monomolecular Multimodal
Imaging Agent for the Somatostatin Receptor” Bioconjugate Chem., 2008, 19, 192–200.
Wang, KH; Roman-Hernandez, G; Grant, RA; Sauer, RT; Baker, TA, “The Molecular Basis of NEnd
Rule Recognition” Molecular Cell, 2008, 32, 406-414.
M?kel?, AR; N?rv?nen, A; Oker-Blom, C, “Peptide-mediated interference with baculovirus
transduction” Journal of Biotechnology, 2008, 134, 20-32.
Fabani MM; Gait, MJ, “miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide
nucleic acids (PNA), and PNA–peptide conjugates” RNA, 2008, 14, 336-346.
Lopes, LB; Furnish, E; Komalavilas, P; Seal, BL; Panitch, A; Vitória, M; Bentley, LB; Brophy, CM,
“Enhanced skin penetration of P20 phosphopeptide using protein transduction domains”
European Journal of Pharmaceutics and Biopharmaceutics, 2008, 68, 441-445.
Neta, P; Pu, Q-L; Yang, X; Stein, SE, “Consecutive neutral losses of H2O and C2H4O from NTerminal
Thr–Thr and Thr–Ser in collision-induced dissociation of protonated peptides: Position
dependent water loss from single Thr or Ser” International Journal of Mass Spectrometry, 2007,
267, 295-301.
Hoyer, KM; Mahlert, C; Marahiel, MA, “The Iterative Gramicidin S Thioesterase Catalyzes Peptide
Ligation and Cyclization” Chemistry & Biology, 2007, 14, 13-22.
McAuley, JL; Hornung, F; Boyd, KL; Smith, AM; McKeon, R; Bennink, J; Yewdell, JW; McCullers,
JA, “Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and
Secondary Bacterial Pneumonia” Cell Host & Microbe, 2007, 2, 240-249.
Lee, J-Y; Choo, J-E; Choi, Y-S; Park, J-B; Min, D-S; Lee, S-J; Rhyu, HK, Jo, I-H; Chung, C-P;
Park, Y-J, “Assembly of collagen-binding peptide with collagen as a bioactive scaffold for
osteogenesis in vitro and in vivo” Biomaterials, 2007, 28, 4257-4267.
Frahm, N; Kaufmann, DE; Yusim, K; Muldoon, M; Kesmir, C; Linde, CH; Fischer, W; Allen, TM;
Li, B; McMahon, BH; Faircloth, KL; Hewitt, HS; Mackey, EW; Miura, T; Khatri, A; Wolinsky, S;
McMichael, A; Funkhouser, RK; Walker, BD; Brander, C; Korber, BT, “Increased Sequence
Chen, C; Kim, J; Liu, D; Rettig, GR; McAnuff, MA; Martin, ME; Rice, KG, “Synthetic PEGylated
Glycoproteins and Their Utility in Gene Delivery” Bioconjugate Chem., 2007, 18 (2), pp 371–378.
Diversity Coverage Improves Detection of HIV-Specific T Cell Responses” J. Immunol., 2007,
179, 6638-6650.
Leavy, TM; Bertozzi, CR, “A high-throughput assay for O-GlcNAc transferase detects primary
sequence preferences in peptide substrates”, Bioorganic & Medicinal Chemistry Letters, 2007,
17, 3851-3854.
Penna, G; Amuchastegui, S; Cossetti, C; Aquilano, F; Mariani, R; Giarratana, N; De Carli, E;
Fibbi, B; Adorini, L, ”Spontaneous and Prostatic Steroid Binding Protein Peptide-Induced
Autoimmune Prostatitis in the Nonobese Diabetic Mouse” J. Immunol., 2007, 179, 1559-1567.
Abes, S; Turner, JJ; Ivanova, GD; Owen, D; Williams, D; Arzumanov, A; Clair, P; Gait, MJ; and
Lebleu, B, “Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide”
Nucleic Acids Res., 2007, 35, 4495-4502.
Samel, SA; Schoenafinger, G; Knappe, TA; Marahiel, MA; Essen, L-O, “Structural and Functional
Insights into a Peptide Bond-Forming Bidomain from a Nonribosomal Peptide Synthetase”
Structure, 2007, 15, 781-79.
Sweeney, TR; Roqué-Rosell, N; Birtley, JR; Leatherbarrow, RJ; Curry, S. “Structural and
Mutagenic Analysis of Foot-and-Mouth Disease Virus 3C Protease Reveals the Role of the ?-
Ribbon in Proteolysis”, J. Virol., 2007, 81, 115-124.
Miller, SA; Tollefson, S; Crowe, JE, Jr.; Williams, JV; Wright, DW, “Examination of a Fusogenic
Hexameric Core from Human Metapneumovirus and Identification of a Potent Synthetic Peptide
Inhibitor from the Heptad Repeat 1 Region”, J. Virol., 2007, 81, 141-149.
Dong, H; Hartgerink, JD, “Role of Hydrophobic Clusters in the Stability of a-Helical Coiled Coils
and Their Conversion to Amyloid-like ?-Sheets”, Biomacromolecules, 2007, 8, 617-623.
Neta, P; Pu, Q-L; Yang, X; Stein, SE. “Consecutive Neutral Losses of H2O and C2H4O from NTerminal
Thr-Thr and Thr-Ser in Collision-Induced Dissociation of Protonated Peptides: Position
Dependent Water Loss from Single Thr or Ser” Int. J. Mass Spec., 2007, 267, 295-301.
Lee, S-H; Moon, JJ; Miller, JS; West, JL. “Poly(Ethylene Glycol) Hydrogels Conjugated with a
Collagenase-Sensitive Fluorogenic Substrateto Visualize Collagenase Activity During Three-
Dimensional Cell Migration” Biomaterials, 2007, 28, 3163-3170.
Jaulent, AM; Fahy, AS; Knox, SR; Birtley, JR; Roqué-Rosell, N; Curry, S; Leatherbarrow, RJ, “A
continuous assay for foot-and-mouth disease virus 3C protease activity” Analytical Biochemistry,
2007, 368, 130-137.
He, J; Eckert, R; Pharm, T; Simanian, MD; Hu, C; Yarbrough, DK; Qi, F; Anderson, MH; Shi, W,
“Novel Synthetic Antimicrobial Peptides against Streptococcus mutans” Antimicrob. Agents
Chemother., 2007, 51, 1351-1358.
Lee, S; Miller, SA; Wright, DW; Rock, MT; Crowe, JE, Jr., “Tissue-Specific Regulation of CD8+ TLymphocyte
Immunodominance in Respiratory Syncytial Virus Infection” J. Virol., 2007, 81, 2349-
2358.
Nuti, F; Paolini, I; Cardona, F; Chelli, M; Lolli, F; Brandi, A; Goti, A; Rovero, P; Papini, AM,
“Fmoc-protected iminosugar modified asparagine derivatives as building blocks for
glycomimetics-containing peptides” Bioorganic & Medicinal Chemistry, 2007, 15, 3965-397.
Lee, J-Y; Choo, J-E; Park, H-J; Park, J-B; Lee, S-C; Jo, I; Lee, S-J; Chung, C-P; Park, Y-J,
“Injectable gel with synthetic collagen-binding peptide for enhanced osteogenesis in vitro and in
vivo” Biochemical and Biophysical Research Communications, 2007, 357, 68-74.
Sweeney, TR: Roqué-Rosell, N; Birtley, JR, Leatherbarrow, RJ; Curry, S, “Structural and
Mutagenic Analysis of Foot-and-Mouth Disease Virus 3C Protease Reveals the Role of the ?-
Ribbon in Proteolysis” J. Virol., 2007, 81, 115-124.
Miller, SA; Tollefson, S; Crowe, JE, Jr.; Williams, JV; Wright, DW, “Examination of a Fusogenic
Hexameric Core from Human Metapneumovirus and Identification of a Potent Synthetic Peptide
Inhibitor from the Heptad Repeat 1 Region” J. Virol., 2007, 81, 141-149.
Lee, S-H; Moon, JJ; Miller, JS; West, JL, “Poly(ethylene glycol) hydrogels conjugated with a
collagenase-sensitive fluorogenic substrate to visualize collagenase activity during threedimensional
cell migration” Biomaterials, 2007, 28, 3163-3170.
Sprague, JE; Li, WP; Liang, K; Achilefu, S; Anderson, CJ, “In vitro and in vivo investigation of
matrix metalloproteinase expression in metastatic tumor models” Nuclear Medicine and Biology,
2006, 33, 227-237.
Penna, G; Amuchastegui, S; Cossetti, C; Aquilano, F; Mariani, R; Sanvito, F; Doglioni, C; Adorini,
L, “Treatment of Experimental Autoimmune Prostatitis in Nonobese Diabetic Mice by the Vitamin
D Receptor Agonist Elocalcitol” J. Immunol., 2006, 177, 8504-8511.
Zarling, AL; Polefrone, JM; Evans, AM; Mikesh, LM; Shabanowitz, J; Lewis, ST; Engelhard, VH;
Hunt, DF, “From the Cover: Identification of class I MHC-associated phosphopeptides as targets
for cancer immunotherapy” PNAS, 2006, 103, 14889-14894.
Bloch, S; Xu, B; Ye, Y; Liang, K; Nikiforovich, GV; Achilefu, S, “Targeting Beta-3 Integrin Using a
Linear Hexapeptide Labeled with a Near-Infrared Fluorescent Molecular Probe” Mol.
Pharmaceutics, 2006, 3, 539–549.
Hekim, C; Leinonen, J, N?rv?nen, A; Koistinen, H; Zhu, L; Koivunen, E; V?is?nen, V; Stenman,UH,
“Novel Peptide Inhibitors of Human Kallikrein 2” J. Biol. Chem., 2006, 281, 12555-12560.
Wagner, B; Schumann, D; Linne, U; Koert, U; Marahiel, MA, “Rational Design of Bacitracin A
Derivatives by Incorporating Natural Product Derived Heterocycles” J. Am. Chem. Soc., 2006,
128, 10513–10520.
Abes, S; Williams, D; Prevot, P; Thierry, A; Gait, MJ; Lebleu, B, “Endosome trapping limits the
efficiency of splicing correction by PNA-oligolysine conjugates” Journal of Controlled Release,
2006, 110, 595-604.
Seal, BL; Panitch, A, “Physical matrices stabilized by enzymatically sensitive covalent crosslinks”
Acta Biomaterialia, 2006, 2, 241-251.
Busson, M; Castelli, FA; Wang, X-F; Cohen, WM; Charron, D; Ménez, A; Maillère, B, “Prediction
of CD4+ T cell epitopes restricted to HLA-DP4 molecules” Journal of Immunological Methods,
2006, 317, 144-151.
Stiffler, MA; Grantcharova, VP; Sevecka, M; MacBeath, G, “Uncovering Quantitative Protein
Interaction Networks for Mouse PDZ Domains Using Protein Microarrays”, J. Am. Chem. Soc.,
2006, 128, 5913-5922.
Chen, C-P; Kim, J; Steenblock, E; Liu, D; Rice, KG, “Gene Transfer with Poly-Melittin Peptides”,
Bioconjugate Chem., 2006, 17, 1057-1062.
Murata, S; Ladle, BH; Kim, PS; Lutz, ER; Wolpoe||, ME; Ivie, SE; Smith, HM; Armstrong, TD;
Emens, LA; Jaffee, EM; Reilly, RT. “OX40 Costimulation Synergizes with GM-CSF Whole-Cell
Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen”
J. Immun. 2006, 176, 974-983.
Sundararajan, N; Mao, D; Chan, S; Koo, T-W; Su, X; Sun, L; Zhang, J; Sung, K; Yamakawa, M;
Gafkem, PR; Randolph, T; McLerran, D; Feng, Z; Berlin, AA; Roth, MB, “Ultrasensitive Detection
and Characterization of Posttranslational Modifications Using Surface-Enhanced Raman
Spectroscopy”, Anal. Chem., 2006, 78, 3543-3550.
Sandberg, SM; Noser, JA; Cataliotti, A; Redfield, MM; Matsuda, Y; Burnett, JC., Jr. “BMPInduced
Activation of cGMP in Human Cardiac Fibroblasts: Interactions with Fibronectin and
Natriuretic Peptide Receptors”, J. Cell. Physiol., 2006, 209, 943-949.
Sewell, SL; Wright, DW, “Biomimetic Synthesis of Titanium Dioxide Utilizing the R5 Peptide
Derived from Cylindrotheca fusiformis”, Chem. Mater., 2006, 18, 3108-3113.
Hekim, C; Leinonen, J; Koistinen, H; Zhu, L; Koivunen, E; Vaisanen, V; Stenman, U-H, “Novel
Peptide Inhibitors of Human Kallilrein 2”, J. Biol. Chem., 2006, 281, 12555-12560.
Cohen, WM; Pouvelle-Moratille, S; Wang, X-F; Farci, S; Munier, G; Charron, D, Menez, A;
Busson, M; Maillere, B, “Scanning the HIV Genome for CD4+ T Cell Epitopes Restricited to HLADP4,
the Most Prevalent HLA Class II Molecule”, J. Immun., 2006, 176, 5401-5407.
Murata, S; Ladle, BH; Kim, PS; Lutz, ER; Wolpoe, ME; Ivie, SE; Smith, HM; Armstrong, TD;
Emens, LA; Jaffee, EM; Reilly, RT, “OX40 Costimulation Synergizes with GM-CSF Whole-Cell
Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen”,
J. Immun., 2006, 176, 974-983.
Samel, SA; Wagner, B; Marahiel, MA; Essen, L-O, “The Thioesterase Domain of the Fengycin
Biosynthesis Cluster: A Structural Base for the Macrocyclization of a Non-ribosomal Lipopeptide”
Journal of Molecular Biology, 2006, 359, 876-889.
Kopp, F; Grünewald, J; Mahlert, C; Marahiel, MA, “Chemoenzymatic Design of Acidic Lipopeptide
Hybrids: New Insights into the Structure-Activity Relationship of Daptomycin and A54145”
Biochemistry, 2006, 45, 10474–10481.
Schracke, N; Linne, U; Mahlert, C; Marahiel, MA, “Synthesis of Linear Gramicidin Requires the
Cooperation of Two Independent Reductases” Biochemistry, 2005, 44, 8507–8513.
Grünewald, J; Kopp, F; Mahlert, C; Linne, U; Sieber, SA; Marahiel, MA, “Fluorescence
Resonance Energy Transfer as a Probe of Peptide Cyclization Catalyzed by Nonribosomal
Thioesterase Domains” Chemistry & Biology, 2005, 12, 873-881.
Zhang, Z; Liang, K; Bloch, S; Berezin, M; Achilefu, S, “Monomolecular Multimodal Fluorescence-
Radioisotope Imaging Agents” Bioconjugate Chem., 2005, 16, 1232–1239.
Zhang, L; Li, B; Zhi, Z; Haynie, DT, “Perturbation of Nanoscale Structure of Polypeptide Multilayer
Thin Films” Langmuir, 2005, 21, 5439–5445.
Chew, GH; Galloway, LC; McIntyre, NR; Schroder, LA; Richards, KM; Miller, SA; Wright, DW;
Merkler, DJ, “Ubiquitin and ubiquitin-derived peptides as substrates for peptidylglycine α-
amidating monooxygenase” FEBS Letters, 2005, 579, 4678-4684.
Mahlert, C; Sieber, SA; Grünewald, J; Marahiel, MA, “Chemoenzymatic Approach to Enantiopure
Streptogramin B Variants: Characterization of Stereoselective Pristinamycin I Cyclase from
Streptromyces pristinaespialis”, J. Am. Chem. Soc., 2005, 127, 9571-9580.
Turner, JJ; Arzumanov, AA; Gait, MJ, “Synthesis, Cellular Uptake and HIV-1 Tat-dependednt
Trans-activation Inhibition Activity of Oligonucleotide Analogues Disulphide-Conjugated to Cell-
Penetrating Peptides”, Nucl. Acids Res., 2005, 33, 27-42.
Zhang, L; Parente, J; Harris, SM; Woods, DE; Hancock, REW; Falla, TJ, “Antimicrobial Peptide
Therapeutics for Cystic Fibrosis”, Antimicrob. Agents Chemother., 2005, 49, 2921-2927.
Birtley, JR; Knox, SR; Jaulent, AM; Brick, P; Leatherbarrow, RJ; Curry, S, “Crystal Structure of
Foot-and-Mouth Disease Virus 3C Protease” J. Biol. Chem., 2005, 280, 11520-11527.
Fumoto, M; Hinou, H; Ohta, T; Ito, T; Yamada, K; Takimoto, A; Kondo, H; Shimizu, H; Inazu, T;
Nakahara, Y; Nishimura, S-I, “Combinatorial Synthesis of MUC1 Glycopeptides: Polymer Blotting
Facilitates Chemical and Enzymatic Synthesis of Highly Complicated Mucin Glycopeptides”, J.
Am. Chem. Soc., 2005, 127, 11804-11818.
Kamiński, ZJ; Kolesińska, B; Kolesińska, J; Sabatino, G; Chelli, M; Rovero, P; B?aszczyk, M;
G?ówka, ML; Papini, AM “N-Triazinylammonium Tetrafluoroborates. A New Generation of Efficient
Coupling Reagents Useful for Peptide Synthesis”, J. Am. Chem. Soc., 2005, 127, 16912-16920.
Reynolds, F; Weissleder, R; Josephson, L, “Protamine as an Efficient Membrane-Translocating
Peptide”, Bioconjugate Chem., 2005, 16, 1240-1245.
Dartois, V; Sanchez-Quesada, J; Cabezas, E; Chi, E; Dubbelde, C; Dunn, C; Granja, J; Gritzen,
C; Weinberger, D; Ghadiri, MR; Parr, TR, Jr., “Systemic Antibacterial Activity of Novel Synthetic
Cyclic Peptides”, Antimicrob. Agents Chemother., 2005, 49, 3302-3310.
Schracke, N; Linne, U; Mahlert, C; Maraheil, MA, “Synthesis of Linear Gramicidin Requires the
Coopreation of Two Independent Reductases”, Biochemistry, 2005, 44, 8507-8513.
Lolli, F; Mulinacci, B; Carotenuto, A; Bonetti, B; Sabatino, G; Mazzanti, B; D'Ursi, AM; Novellino,
E; Pazzagli, M; Lovato, L; Alcaro, MC; Peroni, E; Pozo-Carrero, MC; Nuti, F; Battistini, L;
Borsellino, G.;Chelli, M; Rovero, P; Papini, AM, “An N-glucosylated Peptide Detecting Disease-
Specific Autoantibodies, Biomarkers of Multiple Sclerosis”, PNAS, 2005, 102, 10273-10278.
Jaulent, AM; Leatherbarrow, RJ, “Design, Synthesis and Analysis of Novel Bicyclic and
Bifunctional Protease Inhibitors” Protein Eng. Des. Sel., 2004, 17, 681-687.
Kelly, K; Alencar, H; Funovics, M; Mahmood, U; Weissleder, R, “Detection of Invasive Colon
Cancer Using a Novel, Targeted, Library-Derived Fluorescent Peptide” Cancer Res., 2004, 64,
6247-6251.
Pratt, MR; Hang, HC; Ten Hagen, KG; Rarick, J; Gerken, TA; Tabak, LA; Bertozzi, CR,
“Deconvoluting the Functions of Polypeptide N-α-Acetylgalactosaminyltransferase Family
Members by Glycopeptide Substrate Profiling” Chemistry & Biology, 2004, 11, 1009-1016.
Kelly, KA; Reynolds, F; Weissleder, R; Josephson, L, “Fluorescein isothiocyanate–hapten
immunoassay for determination of peptide–cell interactions” Analytical Biochemistry, 2004, 330,
181-185.
Grünewald, J; Sieber, SA; Mahlert, C; Linne, U; Marahiel, MA, “Synthesis and Derivatization of
Daptomycin” J. Am. Chem. Soc., 2004, 126, 17025–17031.
Galande, AK; Spatola, AF, “Solid-Phase Synthesis of Disulfide Heterodimers of Peptides” Org.
Lett., 2003, 5, 3431–3434.
Godkin, AJ; Smith, KJ; Willis, A; Tejada-Simon, MV; Zhang, J; Elliott, T; Hill, AVS, “Naturally
Processed HLA Class II Peptides Reveal Highly Conserved Immunogenic Flanking Region
Sequence Preferences That Reflect Antigen Processing Rather Than Peptide-MHC Interactions”
J. Immunol., 2001, 166, 6720-6727.
Apex 396平行合成儀的具體信息請聯(lián)系我們，我們擁有經(jīng)驗豐富的工程師，對Apex 396平行合成儀的情況了如指掌，您購買了一臺Apex 396平行合成儀后，會發(fā)現(xiàn)能夠節(jié)省您大量的時間，幫助您愉快高效的完成工作。
Apex 396平行合成儀是您不二的選擇。