灌注系統概述
HSE—HA生理學系統是一系列應用廣泛的完備產品，可用于整體動物生理學、立體或在體器官和組織灌注及組織浴槽研究。這些系統具有廣泛的應用，包括傳統的**藥理學、DMPK、毒理學、呼吸系統、心臟病學、分子生物學和生理學。每個系統都設計了標準的組件，再加一些其他配置以適合特殊研究的需要。。標注組件也意味著如果你是需要將現有設備配齊，或者進行系統升級，或者是完整的配套產品，你都只需要購買需要的構件。HSE-HA生理學系統為你提供各種工具，使你的研究走向多產和成功。
我們提供大多數生理學檢測設備，包括放大器、電極、傳感器和電化學檢測器。參數包括力、位移、壓力、液體和氣體流、心電圖（單導聯—12導聯系統）、MAP（單個或多個部位）、腦電圖、肌電圖、連續支流灌注傳統的血氣參數和電解質的分析，可以選擇程序化軟件和傳統的刺激器作為放大器、電極和傳感器等產品的補充。
HSE-DAQ系統產品家族（BDAS、ACAD、HAEMODYN、ISOHEART、PULMODYN、PENNOCK）可以記錄你的初始信號，計算到處的參數，注釋數據，快速簡易的輸入確定的數據用于分析。同時還可以選擇用于進一步分析的軟件模塊，帶狀記錄紙打印，自動和控制模塊等。產品經過預先設置，打開包裝即可使用，并專門設計符合你的系統配置和數據分析要求。
• Optimized in-situ preparation
• Negative-pressure ventilation to mimic more closely the invivo situation
• Regular induction of hyperinflation of the lung (sigh, augmented breath)
• Several perfusion modes using buffer solution or blood are available:
– Constant flow perfusion
– Constant pressure perfusion
– Dual perfusion system(constant flow or constant pressure can be selected)
• Continuous measurement of lung mechanics (tidal volume, resistance, compliance), and perfusate characteristics (pressure, flow, pO2, pCO2, pH)
• Continuous measurement of lung weight (Edema)
Ventilation
The lung is placed in the artificial thoracic chamber and ventilated at negative pressure, it is connected via the tracheal cannula to the pneumotachometer for measurement of respiratory flow. The humidified ventilation medium (air or gas mixture) is constantly flowing past the distal end of the pneumotachometer.
Perfusion
Lungs can be perfused by either constant flow or constant pressure. Although constant flow perfusion may mimic the in vivo situation more closely, it has the disadvantage that hydrostatic edema becomes inevitable during vasoconstriction. Constant pressure perfusion permits higher perfusate flow rates since vasoconstriction decreases perfusate flow and hydrostatic edema is less likely to occur.
Can be configured in one of three different perfusion modes:
1. Constant Flow Perfusion
2. Constant Pressure Perfusion
3. Dual System to Switch from Constant Flow to Constant Pressure and Vice Versa
Lung Weight Changes
Continuous measurement of weight changes of the lung is required for monitoring edema formation. This is possible during negative pressure ventilation inside the thoracic chamber by using the HSE-Edema balance LS 30 (weight transducer) (BS4 73-0593), range ±
• Optimized in-situ preparation
• Negative-pressure ventilation to mimic more closely the invivo situation
• Regular induction of hyperinflation of the lung (sigh, augmented breath)
• Several perfusion modes using buffer solution or blood are available:
– Constant flow perfusion
– Constant pressure perfusion
– Dual perfusion system(constant flow or constant pressure can be selected)
• Continuous measurement of lung mechanics (tidal volume, resistance, compliance), and perfusate characteristics (pressure, flow, pO2, pCO2, pH)
• Continuous measurement of lung weight (Edema)